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Pets Health

Best Dog Skin & Coat Medications

Updated May 2025
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Pros
Cons
Best of the Best
Elanco Zenrelia
Elanco
Zenrelia
Ideal for Allergic Dermatitis

This tablet effectively reduces itch and inflammation associated with allergy-related skin conditions and is easy to give to most dogs.

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Ideal for Allergic Dermatitis
Bottom Line

This tablet effectively reduces itch and inflammation associated with allergy-related skin conditions and is easy to give to most dogs.

Pros

Its active ingredient, ilunocitinib, reduces the skin's inflammatory response caused by allergies. It treats both allergic dermatitis and atopic dermatitis. It only needs to be taken once a day and can be administered with or without food.

Cons

It requires a prescription. Its side effects include tiredness, vomiting and diarrhea.

Nutramax Welactin Canine Omega-3 Liquid Dog Supplement
Nutramax
Welactin Canine Omega-3 Liquid Dog Supplement
Skin-nourishing Formula

A drug-free option to ease your dog's skin and coat problems. It's a plus that most dogs love the flavor.

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Skin-nourishing Formula
Bottom Line

A drug-free option to ease your dog's skin and coat problems. It's a plus that most dogs love the flavor.

Pros

A supplement that is effective at calming itchy skin for most canines. Makes fur soft and shiny. Made with fish oil that's packed with omega-3 fatty acids that are beneficial to the skin. The liquid form is easy to give with food. No prescription required.

Cons

Not ideal for serious skin problems, and won't treat infections. Some reports of leaky bottles.

Derm-Tabs Regular Strength Liver Flavored Chewable Tablet Skin & Coat Supplement for Dogs
Derm-Tabs
Regular Strength Liver Flavored Chewable Tablet Skin & Coat Supplement for Dogs
Easy to Administer

These flavored tablets make it easy to keep your dog's skin and coat healthy and itch-free with a blend of natural ingredients.

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Easy to Administer
Bottom Line

These flavored tablets make it easy to keep your dog's skin and coat healthy and itch-free with a blend of natural ingredients.

Pros

It features a blend of vitamins, minerals and natural oils, as well as antioxidants and omega-3 and omega-6 fatty acids, that help keep the skin and coat healthy and reduce excessive shedding. The tablets feature a liver flavor that dogs love.

Cons

There are sometimes moisture issues with the packaging, which can leave some of the tablets unusable.

Vetnique Labs Dermabliss Medicated Anti-Bacterial & Anti-Fungal Chlorhexidine Infection Dog & Cat Skin Spray
Vetnique Labs
Dermabliss Medicated Anti-Bacterial & Anti-Fungal Chlorhexidine Infection Dog & Cat Skin Spray
For Bacterial and Fungal Infections

This easy-to-use spray can help soothe infections like yeast dermatitis, making your dog more comfortable in just a few days.

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For Bacterial and Fungal Infections
Bottom Line

This easy-to-use spray can help soothe infections like yeast dermatitis, making your dog more comfortable in just a few days.

Pros

Its active ingredients treat both bacterial and fungal skin infections in dogs. Its spray formula makes it very easy to apply. It helps eliminate odors associated with skin infections. It is made in the United States.

Cons

Some users complain that the spray mechanism can get stuck and cause a mess during application.

Bark&Spark Soft Chewable Omega-3 Supplement, 180 Pieces
Bark&Spark
Soft Chewable Omega-3 Supplement, 180 Pieces
Easiest to Use

Easy-to-use and chewable, these chicken-flavored supplements support healthy hips and joints alongside dry and itchy skin.

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Easiest to Use
Bottom Line

Easy-to-use and chewable, these chicken-flavored supplements support healthy hips and joints alongside dry and itchy skin.

Pros

Packed with omega-3, which is great for irritated skin. Dogs who don't like creams and lotions can chew this product like a treat. You receive up to a three-year supply of treats. They aim for a natural flavor that won't be off-putting to picky eaters.

Cons

Some dogs still don't like the salmon flavor of this product, but most appear to enjoy it.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 
HOW WE TESTED

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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First Reviewed
November 09, 2021
51
Models
considered
8
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researched
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Jennifer Manfrin
Written by Jennifer Manfrin

Updated May 2025

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The majority of pooches experience skin issues during their lifetimes. Parasites, immune system issues, and allergies are some of the most common agitators that can cause skin to become red, itchy, and even infected. When these problems occur, canine coats suffer too, resulting in loss of fur, odors, and dull, dry coats. But there's no need to stress if your dog has a troubling skin or coat condition, because there are medications that can help relieve symptoms as well as improve your pet's coat. Start by consulting with your veterinarian to find the medication that will work best for your dog's problem. Keep in mind that some medications require prescriptions to purchase.

Our Top Picks
Elanco
Best of the Best
Elanco
Zenrelia
Bottom Line
This tablet effectively reduces itch and inflammation associated with allergy-related skin conditions and is easy to give to most dogs.
Shop Now
Nutramax
Best Bang for the Buck
Nutramax
Welactin Canine Omega-3 Liquid Dog Supplement
Bottom Line
A drug-free option to ease your dog's skin and coat problems. It's a plus that most dogs love the flavor.
Shop Now
Derm-Tabs
Top Pick
Derm-Tabs
Regular Strength Liver Flavored Chewable Tablet Skin & Coat Supplement for Dogs
Bottom Line
These flavored tablets make it easy to keep your dog's skin and coat healthy and itch-free with a blend of natural ingredients.
Shop Now
Vetnique Labs
Top Pick
Vetnique Labs
Dermabliss Medicated Anti-Bacterial & Anti-Fungal Chlorhexidine Infection Dog & Cat Skin Spray
Bottom Line
This easy-to-use spray can help soothe infections like yeast dermatitis, making your dog more comfortable in just a few days.
Shop Now
Bark&Spark
Top Pick
Bark&Spark
Soft Chewable Omega-3 Supplement, 180 Pieces
Bottom Line
Easy-to-use and chewable, these chicken-flavored supplements support healthy hips and joints alongside dry and itchy skin.
Shop Now
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