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Best Dog Pain Relief & Arthritis Medications

Updated May 2025
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Pros
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Best of the Best
Vet's Best Ache + Pains Dog Supplement
Vet's Best
Ache + Pains Dog Supplement
Best for Occasional Pain

This supplement is ideal for occasional pain from regular exercise and activity and features a natural formula that works for most dogs.

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Best for Occasional Pain
Bottom Line

This supplement is ideal for occasional pain from regular exercise and activity and features a natural formula that works for most dogs.

Pros

It is a plant-based formula that contains popular joint pain relief ingredient glucosamine HCL, as well as pineapple bromelain, MSM, and white willow bark. It helps sore and stiff muscles and joints triggered by aging. The chewable tablets are easy for most dogs to take. It is suitable for active, large-breed, or senior dogs.

Cons

The tablets have a strong pineapple odor and flavor, which some dogs don't like, so they may need to be hidden in food.

Nutri-Vet Aspirin for Dogs
Nutri-Vet
Aspirin for Dogs
Best for Large to Medium Dogs

These specially formulated tablets are highly effective in temporarily relieving pain in dogs weighing 50 pounds or more.

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Best for Large to Medium Dogs
Bottom Line

These specially formulated tablets are highly effective in temporarily relieving pain in dogs weighing 50 pounds or more.

Pros

The tablets contain 300 mg of aspirin, so dogs between 50 and 100 pounds only need to take one tablet every 12 hours, and those over 100 pounds only need two tablets. The formula targets pain associated with arthritis, joint issues, and minor injuries. The tablets are liver-flavored, which many dogs love.

Cons

Some dogs experience vomiting and diarrhea after taking these tablets.

MediNatura T Relief Pet Pain Liquid Drops
MediNatura
T Relief Pet Pain Liquid Drops
Best Liquid Pain Reliever

This plant-based pain relief liquid is easy to administer and won't upset your dog's stomach while it helps soothe aches and pains.

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Best Liquid Pain Reliever
Bottom Line

This plant-based pain relief liquid is easy to administer and won't upset your dog's stomach while it helps soothe aches and pains.

Pros

It uses natural, plant-based ingredients, including arnica, calendula, echinacea, and hypericum, to relieve muscle and joint pain or discomfort. The formula is safe for everyday use. It can be administered directly into your pet's mouth or mixed with a small amount of food or water. It doesn't have any known drug interactions.

Cons

Some users report that the bottle can leak during shipping, so the product may arrive with some of the liquid missing.

Grateful Pawz Hip + Joint Glucosamine Hemp Treats
Grateful Pawz
Hip + Joint Glucosamine Hemp Treats
Best for All Dog Breeds & Sizes

These tasty chews contain natural ingredients that help protect bones and cartilage for improved joint health in dogs of all sizes.

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Best for All Dog Breeds & Sizes
Bottom Line

These tasty chews contain natural ingredients that help protect bones and cartilage for improved joint health in dogs of all sizes.

Pros

They contain glucosamine, chondroitin, MSM, and green-lipped muscles to help effectively lubricate joints. They work well for occasional joint stiffness and joint mobility maintenance. They have a natural chicken flavor that even picky dogs love. They are made in the United States and don't contain any fillers, GMOs, or sugar.

Cons

They have a very strong odor that some users report is similar to horse manure.

PetArmor Canine Aspirin for Small to Medium Dogs
PetArmor
Canine Aspirin for Small to Medium Dogs
Best for Small to Medium Dogs

These chewable tablets temporarily relieve minor aches and pains for dogs between 10 and 50 pounds.

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Best for Small to Medium Dogs
Bottom Line

These chewable tablets temporarily relieve minor aches and pains for dogs between 10 and 50 pounds.

Pros

It effectively provides temporary relief for aches and pains associated with joint issues. It can help improve mobility for senior dogs. The chewable tablets feature a liver flavor that many dogs love. The dosage is just one to two tablets based on the dog's weight.

Cons

Some users report side effects like vomiting and diarrhea, especially in dogs with other health conditions, and recommend consulting with your vet before administering.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 
HOW WE TESTED

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

First Reviewed
November 07, 2021
30
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22
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researched
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Buying guide for best dog pain relief and arthritis medications

michelle
Written by michelle

Updated May 2025

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Just as humans are prone to more aches and pains as they grow older, so, too, is your dog. But while you’re able to seek medical attention on your own for health concerns, your pooch is entirely dependent on your care. Dogs do suffer from arthritis and other painful conditions as they grow older, but just because these health issues are common doesn’t mean you should ignore them. There are medications specifically made for dogs to address these issues and help your pet be more comfortable.

It’s important that you not write off any signs of pain in your pet, such as limping or lethargy, as normal signs of canine aging. Luckily, there are quite a few dog pain relief and arthritis medications available, both by prescription and over the counter.

If Fido doesn’t seem to be quite himself these days, it’s time for a visit to the vet to pinpoint the problem and figure out a solution.  Our buying guide contains helpful information about some of the treatments your dog’s veterinarian is likely to recommend. We’ve included some of our favorites, too.

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Aging is a normal part of a dog’s life, but pain doesn’t have to be. There are very effective medications available to keep your dog feeling its best.

Key considerations

OTC medications

There are several pain relief and arthritis treatments for dogs that are available without a prescription. Most are intended to proactively ward off arthritis pain and inflammation before it gets severe rather than treat pain that’s already occurring. Over-the-counter (OTC) supplements and treatments are excellent options if your dog is only occasionally showing mild signs of arthritis, or if you hope to keep your aging pooch feeling its best. Most of these treatments include a blend of active ingredients. The following are some of the most common:

Glucosamine: This combination of glutamine and glucose is produced naturally in dogs’ bodies, but production slows as they age. Glucosamine supplements help lubricate the joints, as well as encourage the growth of healthy cells and repair of damaged cells in cartilage.

Chondroitin: Another natural substance, chondroitin helps prevent the breakdown of cartilage in aging joints. It’s particularly effective when paired with glucosamine.

MSM: Methylsulfonylmethane is a natural anti-inflammatory and pain reliever.

Omega-3 fatty acids: Omega-3 fatty acids improve health in a variety of ways, one of which is the reduction of inflammation that leads to joint pain.

Boswellia serrata: This herbal supplement has strong anti-inflammatory and pain-reducing abilities.

Curcumin: Sourced from the spice turmeric, curcumin has anti-inflammatory qualities and also helps reduce pain.

Aspirin: While aspirin for dogs is sold without a prescription, it’s best to talk with your dog’s veterinarian before using it to relieve your pooch’s discomfort, because excessive use can lead to ulcers and digestive system bleeding. Be sure to use only aspirin dosed for dogs and buffered to protect your dog’s stomach. 

Prescription medications

While OTC supplements can help ward off the earliest stages of arthritis pain, it’s quite possible that eventually your dog will need something stronger. Your veterinarian can prescribe one of several medications to effectively reduce your dog’s discomfort and help it enjoy its golden years. These are some of the most common prescription pain relievers for dogs.

NSAIDs: Non-steroidal anti-inflammatory drugs are the largest group of prescription medications used to treat arthritis and other painful conditions in dogs. While their pharmacology is complex, basically, NSAIDs work by reducing the production of prostaglandin, a chemical released by cells that has several important functions throughout the body but also causes inflammation, pain, and fever.

You may well take NSAIDs yourself to treat your own arthritis, headache, or other painful conditions–ibuprofen and naproxen are two very common NSAIDs that are both available over the counter–but do not share your pain treatments with your pooch. Your dog’s digestive system, liver, and kidneys handle drugs differently than your organ systems, and what is a safe treatment for your condition could be harmful or even fatal to your dog. Instead, your veterinarian can prescribe NSAIDs specifically formulated for canines and dosed to your dog’s weight.

While most dogs can take NSAIDs without problems for long-term effective treatment of arthritis, there is always the potential for side effects. The most common side effects to watch for include the following:

  • Diarrhea
  • Vomiting
  • Reduced appetite
  • Lethargy or reduced activity level
     

If you notice any changes in your dog’s health or behavior after starting an NSAID, call your veterinarian.

Tramadol: An opioid painkiller, tramadol is often prescribed short-term to reduce post-surgical pain in dogs. It’s also sometimes prescribed as a long-term treatment for arthritis, cancer pain, or other painful conditions that don’t respond well to NSAIDs, or as an adjunct to NSAID therapy. Unlike NSAIDs, tramadol doesn’t treat the cause of pain but instead affects the brain’s ability to process pain messages transmitted by nerves. Most dogs can safely take tramadol, but call your veterinarian if your pooch experiences any of the following side effects:

  • Vomiting
  • Diarrhea
  • Constipation
  • Tremors
  • Loss of appetite
  • Dizziness or instability while walking
  • Excessive sedation or drowsiness
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Did you know?
NSAIDs are the most common prescription dog pain medications for treating arthritis.
STAFF
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Dog medication prices

Because there are so many types of dog pain relief and arthritis medications, and because they are sold both over the counter and by prescription, the price range is a wide one. But still, these treatments are typically not too expensive, and it’s hard to put a price tag on your dog’s well-being.

As a general rule, you’ll pay a lot more for prescription medications directly from your veterinarian. If your dog will be taking the medication long-term, it’s normally much less expensive to order the drug through an online pet pharmacy. Keep in mind that many factors influence the cost of a medication, including dosage and whether it’s a brand name or a generic. Here are some very rough guidelines:

NSAIDs: Most prescription NSAIDs cost from $15 to $40 for 30 doses.

Tramadol: This costs around $25 to $30 for 30 doses.

OTC supplements: These typically cost between $20 and $35 for a supply that lasts one to two months.

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Caution
Never give your cat any medication prescribed for your dog. Felines do not metabolize medications in the same way dogs do, and the results could be disastrous.
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BestReviews

Tips

While medication plays an important role in keeping your canine free of arthritis pain, there are lifestyle changes that can also help reduce discomfort.

  • Keep your dog at a healthy weight. This is very important. Excess weight puts more stress on already painful joints. Talk to your vet about dietary changes, if necessary.
  • Keep your dog moving. Even though your dog might not be able to accompany you on long jogs anymore, it’s still important to keep it moving. Several short walks each day help keep joints lubricated and prevent stiffness. It’s especially helpful to walk up and down hills.
  • Give your dog a padded bed. A cozy, padded bed will keep your aging canine comfortable while it snoozes. Orthopedic foam provides exceptional support for sore joints. If your dog sleeps outdoors, a heated bed is a must during the winter.
  • Install a ramp. Doggy ramps make it easier for arthritic or elderly pooches to get on and off the couch or your bed, as well as for larger dogs to get into the car.
  • Provide traction on slick floors. Aging dogs sometimes have difficulty walking on smooth floors such as wood or tile. Give your dog assistance by laying down area rugs over nonslip pads where needed to provide more traction.
  • Try alternative treatments. Massage, acupuncture, water therapy, and laser therapy are all options for helping your arthritic dog feel better.
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If your dog shows signs of pain, including limping, stiffness, or loss of appetite, it’s time for a visit to your veterinarian.

FAQ

Q. Can I give my dog OTC pain meds intended for humans?
A.
Unless it’s under the direction of your veterinarian, never give your dog common OTC human pain relievers, including Tylenol, Advil (ibuprofen), Aleve (naproxen) or regular aspirin. All of these medications can be toxic to dogs in large doses, potentially causing kidney or digestive system damage.


Q. Can my cat take the same pain medications as my dog?
A.
Just because Fido and Fluffy share a bed and a water bowl doesn’t mean they can share medications. Never give your cat a pain medication prescribed for your dog, particularly an NSAID. Cats are much more sensitive to these drugs, and their bodies do not metabolize them well, leading to potentially serious side effects. There are pain medications for cats, including specially formulated NSAIDs, so if you have an arthritic feline, talk to your vet about treatment options.


Q. How do I know if my dog is in pain?
A.
Your pooch can’t tell you directly that it’s hurting, but it can show pain through body language and behavior. Arthritis and other painful conditions often show through these symptoms:

  • Limping or favoring one leg
  • Difficulty standing, especially after sleeping
  • Loss of appetite
  • Refusal to use stairs
  • Difficulty jumping up onto a favorite couch or chair
  • Reduced activity, such as sleeping more
  • Aggression or irritability
  • Yelping or crying when trying to stand or walk
  • Shivering or panting
  • Tail tucked instead of wagging freely
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